منابع مشابه
Interpreting subgroup analyses: is a school-based asthma treatment program's effect modified by secondhand smoke exposure?
H alterman et al 1 present a randomized controlled trial (RCT) of a school-based asthma treatment program in this issue of the ARCHIVES. The authors enrolled 184 children with asthma 3 to 7 years of age from 1 school district. Children were identified via a school health form and were eligible for enrollment if at least mild persistent asthma was confirmed and the primary care physician (PCP) a...
متن کاملSubgroup analyses in Orgalutran trials.
I read with interest the European–Middle East Orgalutran trial (The European Orgalutran Study Group et al., 2000) and I noticed that the study extensively monitored hormonal assays (LH, FSH, oestradiol). It is well known that sufficient stimulation of both theca cells and granulosa cells by LH and FSH is required for adequate oestradiol biosynthesis (Short, 1962; Schoot et al., 1992) and hence ...
متن کاملConsiderations on Subgroup Analyses in Clinical Trials.
As clinicians, we routinely treat patients with drugs whose efficacy is supported by evidence from multicenter clinical trials, some of which include thousands of patients from different parts of the world. When it comes to treating a given patient, however, we need to know whether the beneficial effect described for the average patient will apply to this patient in particular. This can be done...
متن کاملStatistics in medicine--reporting of subgroup analyses in clinical trials.
Medical research relies on clinical trials to assess therapeutic benefits. Because of the effort and cost involved in these studies, investigators frequently use analyses of subgroups of study participants to extract as much information as possible. Such analyses, which assess the heterogeneity of treatment effects in subgroups of patients, may provide useful information for the care of patient...
متن کاملChallenges and Solutions to Pre- and Post-Randomization Subgroup Analyses
Subgroup analyses are commonly performed in the clinical trial setting with the purpose of illustrating that the treatment effect was consistent across different patient characteristics or identifying characteristics that should be targeted for treatment. There are statistical issues involved in performing subgroup analyses, however. These have been given considerable attention in the literatur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Pediatrics & Adolescent Medicine
سال: 2004
ISSN: 1072-4710
DOI: 10.1001/archpedi.158.5.469